Abstract
In order to see the disposal ability of pyruvate in diabetic patients, the exogenous or endogenous hyperpyruvaemia was produced by the intravenous infusion of 10g. of sodium pyruvate or 10g. of fructose in 19 diabetic patients and 18 nondiabetic subjects and the urinary excretion of pyruvic acid, citric acid and α-ketoglutaric acid was observed hourly for three hours. The results revealed that there were no significant differences in the changes of these organic acids excretion after pyruvate or fructose injection between the diabetic group and the nondiabetic group. This indicates that no primary metabolic defect exists at the step where pyruvic acid enters TCA cycle.
