1964 Volume 82 Issue 4 Pages 327-348
In order to clarify the pathogenesis of neurogenic bladder, selective section of nerves innervating the urinary bladder was performed in adult dogs, and physiological, histological, and biochemical observations were carried out. The results obtained are as follows:
1) A marked inflammatory picture was found in the vesical wall, as well as in the ureter and the kidney, and subsequent pyelonephritis was assumed. 2) The cystometrogram, as well as the cystogram, revealed a characteristic change of vesical wall after the nerve section, and it was well correspondent to the kind of nerve section. 3) Tissue metabolic pattern of vesical wall was changed corresponding to the kind of nerve section, and it was thought that these changes would be developed through the alterative change in the tissue electron transfer system induced by the nerve section. 4) The vesical dysfunction was demon-strated in alloxan diabetic dogs relating to the degeneration of nerve fibers. 5) The pathogenesis of vesico-ureteral reflux, and the effect of additional section of spinal nerves, and furthermore the effect of relating therapeutic agents were examined.
