The distribution of body defence energy was studied from the standpoint of the hematopoietic phases of the bone-marrow and the fields and times of blood defense reaction. It was found that the sum of energy poured into the field of cell-bacterium reaction and the field of antibody-antigen reaction is equal to the defense energy of the body, and the law of conservation of defense energy is entirely the same as Mayer-Joule-Helmholtz's law of conservation of energy. From this law, it is construed that the cell-bacterium reaction and antibody-antigen reaction show a constant-antagonistic relation. The cells playing celll-bacterium reaction, especially neutrophils, show less qualitative changes but more quantitative changes in response to stimulations, and the cells playing antibody-antigen reaction, especially lymphocytes, show less quantitative changes but more qualitative changes by stimulations. Therefore, while the absolute count of leucocytes does not show the distribution of defense energy, their percentage shows the distribution of defense energy, adaptation of the body and characteristics of stimulant factors, and then the biological and clinical value of their percentage is far superior as compared with absolute count.
In order to count the nucleated cells in the bone-marrow, the generally adopted method which makes total nucleated cells as 100%, is inconvenient and unreasonable from the standpoint of the hematopoietic phases in the bone-marrow and the fields and times of blood defense reaction. Rohr's counting method is excellent and reasonable as calculating method of the nucleated cells in the bone-marrow.
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