Abstract
The authors have observed the change in the blood pressure and histological changes in the kidney of adult dogs in which the renal artery was experimentally constricted. The results obtained show that the sclerotic changes occurred gradually in the glomeruli, Bowman's capsules, intorstitiums, and renal vessels about 3 weeks after the operation. We have also studied the effect of angiotensin on the kidney and some other organs by injecting it to rats. It was found. that the sclerotic changes of the glomeruli, Bowman's capsules, and the renal vessels occurred 10 days after the injection and tended to progress gradually.
