Abstract
Resibufogenin, one of the principles isolated from “Sense”, the dried toad venom, has been reported by several investigators to exhibit cardiotonic, vaso-pressor as well as respiratory stimulating action. In this study the cardiovascular effects of Resibufogenin as a vasopressor agent were investigated in dogs as well as in clinical cases. The experimental results showed that the vasopressor effect of Resibufogenin seemed to be predominantly due to its peripheral vasoconstrictor action, although partly duo to its cardiotonic action. An intravenous dose of 0.11 mg/kg of Resibufogenin resulted in an increase in systolic blood pressure by about 25-35% of the previous levels in clinical cases without causing any disturbances of cardiac rhythms under various anesthetic agents. The vasopressor effect appeared to be more remarkable in those patients with greater fall in blood pressure prior to its administration. Resibufogenin seemed to be used safely as a vasopressor agent even under cyclopropane, halothane as well as methoxyflurane anesthesia.
