The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 86, Issue 2
Displaying 1-7 of 7 articles from this issue
  • Kenichi Iwatsuki, Tsuneo Yusa, Yoshifumi Kataoka, Kazuya Sato
    1965 Volume 86 Issue 2 Pages 93-101
    Published: July 25, 1965
    Released on J-STAGE: November 28, 2008
    Resibufogenin, one of the principles isolated from “Sense”, the dried toad venom, has been reported by several investigators to exhibit cardiotonic, vaso-pressor as well as respiratory stimulating action. In this study the cardiovascular effects of Resibufogenin as a vasopressor agent were investigated in dogs as well as in clinical cases. The experimental results showed that the vasopressor effect of Resibufogenin seemed to be predominantly due to its peripheral vasoconstrictor action, although partly duo to its cardiotonic action. An intravenous dose of 0.11 mg/kg of Resibufogenin resulted in an increase in systolic blood pressure by about 25-35% of the previous levels in clinical cases without causing any disturbances of cardiac rhythms under various anesthetic agents. The vasopressor effect appeared to be more remarkable in those patients with greater fall in blood pressure prior to its administration. Resibufogenin seemed to be used safely as a vasopressor agent even under cyclopropane, halothane as well as methoxyflurane anesthesia.
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  • Shungo Osato
    1965 Volume 86 Issue 2 Pages 102-147
    Published: July 25, 1965
    Released on J-STAGE: November 28, 2008
    In the present paper I have reviewed results of our clinical investigations in chemotherapeutic treatment of carcinoma, and changes of the histological aspects of carcinoma tissue under treatment at different stages. As to the remedies, we used mostly citronellal per os and citral in the form of emulsion as intramuscular injection exclusively. In some other cases we combined anti-cancer remedies as Nitromin, Merphyrin and others. Both citronellal and citral are aldehydes of turpentine series with C10. Of the 121 cases, which were observed from Oct., 1944 to March, 1959, 6 (_??_5%) were permanently cured, having been followed up from 10 to 15 years.
    Seven cases of removed stomach cancer in the course of treatment from 15 days to one year and four autopsy cases, of those who died suddenly or in rather short duration because of intercurrent occurrences during favorable course are our materials for histological investigation. They were thoroughly examined micro-scopically. It was revealed that under the action of remedies, first the degenera-tion of tumor cells followed by infiltration of plasma cells and other mesenchymal cells take place; then abundant proliferation of connective tissue throughout the carcinoma tissue occur. In this way carcinoma cells and carcinoma tissue got encapsulated, divided by connective tissue and completely annihilated. In rather advanced cases healing of carcinoma under cicatrization would be expected. But in early case of carcinoma, healing without leaving remarkable cicatrice is possible, as was verified in the case of stomach carcinoma, removed after 7 months' treatment.
    Possibility of acceleration of healing process through antigen-autoantibody reaction between carcinoma cells and antibody produced in the host during the course of chemotherapy is surmised. In this case there will naturally be severe stress, so that it would be favorable only when the patient could overcome the reaction.
    It is noted that here in Akita Prefectural Central Hospital we treated during 2 years and a half 25 cases of carcinoma, of which 3 are completely cured.
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  • Takashi Kitabatake
    1965 Volume 86 Issue 2 Pages 148-159
    Published: July 25, 1965
    Released on J-STAGE: November 28, 2008
    This paper deals with an evaluation of radiation dose received by X-ray workers in the past days of Japan. For this evaluation, radiation dose received by X-ray workers is considered to be influenced by the following six factors: that is, attention to X-ray protection, sensitivity of X-ray films, sensitivity of intensifying screens, shield of control board, shield of X-ray tube, and quantity of X-ray work. Collection of data from actual history of radiological work in the hospitals and from literature was made and comparable considerations were given on these data between in the past and at present. The most suitable evaluation of radiation dose per year received by individual X-ray worker is considered to be 0.31 R at present, 1.55 R before 1957, 9.3 R before 1953, 90 R before 1945, 240 R before 1940, 350 R before 1935, 520 R before 1930, 680 R before 1926. and 900 R before 1921.
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  • Zensaku Yosizawa, Eiaki Tsutsumi, Minro Watanabe
    1965 Volume 86 Issue 2 Pages 160-167
    Published: July 25, 1965
    Released on J-STAGE: November 28, 2008
    Scrapings of intestinal mucosae from sarcoma (subcutaneous Yoshida-sarcoma)-bearing rats were incubated, in vitro, with U-14C-glucose, comparing with those from normal rats. The resulting 14C-labelled products were fractionated into three carbohydrate fractions: polysaccharide-containing fraction (PS); carbohydrate fraction eluted with 50% aqueous ethanol from the charcoal-absorbed substances (Et); carbohydrate fraction eluted with aqueous ethanol-ammonia from the charcoal-absorbed substances (Et-Am). Monosaccharide components in these carbohydrate fractions were separated by paper chromatography after acidic hydrolysis and the radioactivities incorporated into these sugars were determined.
    The results showed that glucose-14C incorporated much more into monosac-charide components of the three carbohydrate fractions from the sarcoma-bearing animals than those from normal rats. No remarkable difference was found on the ratios of radioactivities incorporated into the fractions of glucosamine and galactosamine and also on the analyzed three monosaccharides contents between normal and the sarcoma-bearing conditions.
    The effects of sarcoma on the metabolism of hexosamine-containing carbohydrates were discussed.
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  • Tetsuo Maki, Noriyoshi Suzuki
    1965 Volume 86 Issue 2 Pages 168-177
    Published: July 25, 1965
    Released on J-STAGE: November 28, 2008
    The persimmon-bezoar, a kind of phytobezoar which is caused by overeating the astringent persimmon fruit, is generally understood to develop as a result of conversion of soluble shibuol, a specific constituent of the astringent persimmon fruit, into insoluble shibuol by the effect of gastric hydrochloric acid. How-ever, according to the present experiment, inasmuch as only soft flocks are formed when hydrochloric acid is added to a suspension of fine skin pieces of the persimmon fruit, such an explanation seems to be insufficient. The authors ap-plied their basic theory of solidification of colloidal substances in living organism (Tohoku J. exp. Med., 1964, 84, 259) to this problem and succeeded in preparing in vitro a bezoar-like solid concrement using persimmon fruits, which proved the propriety of this theory in this case.
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  • Yutaka Kaneko
    1965 Volume 86 Issue 2 Pages 178-190
    Published: July 25, 1965
    Released on J-STAGE: November 28, 2008
    In an attempt to clarify the aspect of the acetylcholine (Ach) metabolism occurring within the cochlea of the guinea-pig, determinations of aeetylcholin-esterase (ChE) activity within it have been made, and the alteration of ChE under pathological conditions was studied. The animals were exposed to sounds or were given D.H.S.M. and D.F.P. systemically. The ChE activity was quantitatively determined with use of Cartesian diver respirometer. By the freezing and melting procedures, the ChE activity was expressed in terms of “functional and reserve ChE.”
    The following results were obtained:
    1) In normal specimens, ChE activity per mm in the lower coil was greater than in the upper coil, but by the freezing and melting procedure, its activity increased in both coils within a similar range.
    2) In the tissues of the sound-exposed animals, functional ChE diminished in the lower coil, while reserve ChE in the upper coil diminished.
    3) In the tissues of the D.F.P.-injected animals, both functional and reserve ChE slightly diminished in the both coils.
    4) In the tissues of the D.H.S.M.-injected animals, considerable individual differences of ChE were characteristic, though both types of ChE decreased on the average.
    5) ChE in the cochlea showed a tendency to change its activity characteristic-ally under each above-mentioned pathological condition.
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  • Kazuko Ishii, Kosei Ishii, Kazumasa Honda
    1965 Volume 86 Issue 2 Pages 191-200
    Published: July 25, 1965
    Released on J-STAGE: November 28, 2008
    The effects of electrical stimulation of the carotid sinus nerve on the shivering, blood pressure and respiration in rabbits were studied.
    According to the pulse duration or intensity of rectangular wave, the stimula-tion of the carotid sinus nerve provoked three types of responses: Type I, inhibition of shivering accompanied by the rise of blood pressure, which was due to the chemosensory activity; Typo II, increase of shivering with extreme fall of blood pressure, being attributed to barosensory excitation; and Type III, inhibition of shivering and the fall of blood pressure. This type of responses was considered to be the intermediate between Types I and II. Respiration always increased.
    The authors confirmed that the shivering was regulated excitatively by the carotid baroreceptor, which was reported previously in this journal, and inhibitively by chemoreceptor.
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