In the present paper I have reviewed results of our clinical investigations in chemotherapeutic treatment of carcinoma, and changes of the histological aspects of carcinoma tissue under treatment at different stages. As to the remedies, we used mostly citronellal per os and citral in the form of emulsion as intramuscular injection exclusively. In some other cases we combined anti-cancer remedies as Nitromin, Merphyrin and others. Both citronellal and citral are aldehydes of turpentine series with C
10. Of the 121 cases, which were observed from Oct., 1944 to March, 1959, 6 (_??_5%) were permanently cured, having been followed up from 10 to 15 years.
Seven cases of removed stomach cancer in the course of treatment from 15 days to one year and four autopsy cases, of those who died suddenly or in rather short duration because of intercurrent occurrences during favorable course are our materials for histological investigation. They were thoroughly examined micro-scopically. It was revealed that under the action of remedies, first the degenera-tion of tumor cells followed by infiltration of plasma cells and other mesenchymal cells take place; then abundant proliferation of connective tissue throughout the carcinoma tissue occur. In this way carcinoma cells and carcinoma tissue got encapsulated, divided by connective tissue and completely annihilated. In rather advanced cases healing of carcinoma under cicatrization would be expected. But in early case of carcinoma, healing without leaving remarkable cicatrice is possible, as was verified in the case of stomach carcinoma, removed after 7 months' treatment.
Possibility of acceleration of healing process through antigen-autoantibody reaction between carcinoma cells and antibody produced in the host during the course of chemotherapy is surmised. In this case there will naturally be severe stress, so that it would be favorable only when the patient could overcome the reaction.
It is noted that here in Akita Prefectural Central Hospital we treated during 2 years and a half 25 cases of carcinoma, of which 3 are completely cured.
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