Abstract
The initial site and the extension of tumor growth in the kidney in hematoge-nous metastasis were investigated by inoculating a certain number of tumor cells into the kidney via the renal artery.
The emboli of tumor cells were observed in the glomerular capillaries and the arterioles immediately after the inoculation. The embolized cells used to decrease or disappear showing degenerating signs within a few days. Five days later, the tumor cells increased in the glomerular capillaries, filling the glomerulus. And then some tumor cells were seen in the Bowman's space and the tumor extended into the tubulus through the proximal convolution. Tumor cells failed to extend out through the basement membrane of the Bowman's capsules or tubuli. No metastatic focus was observed in other site in the kidney. In some animals, slight hematuria was observed in the urine of the bladder, although no tumor cells were detected in the urine within the time of observation.
Mechanisms of hematogenous metastasis in the kidney, and the implanta- tion metastasis into the lower urinary tract were discussed on the basis of the results obtained in the experiment.
