The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Homocystinuria: Amino Acid Pattern of the Liver
Keiya Tada, Toshio Yoshida, Haruko Hirono, Tsuneo Arakawa
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1967 年 92 巻 4 号 p. 325-332

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Free amino acid pattern was determined by an automatic amino acid analyzer in a biopsy spacimen of the liver from a patient with homocystinuria and from three control individuals. An accumulation of homocystine was demonstrated in the homocystinuric liver. The concentration of methionine was found to be higher in the homocystinuric liver than in controls' liver. On the contrary, the concentration of cvstine was found to be lower in the former than in the latter. Free amino acid patterns in the urine, serum and cerebrospinal fluid from the patient were also determined.
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