The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
The Influence of High and Low Potassium Diet on the Sodium Retaining Effect of Desoxycorticosterone Acetate in Dogs
Toshio Nakajima
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1968 年 95 巻 1 号 p. 55-62

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Despite various theories on the mechanism of the appearance of DOCA escape, the nature of this phenomenon still remains unknown. In this study the influence of a high or low potassium diet on the sodium retaining effect of DOCA was investigated in dogs.
A low potassium diet facilitated the appearance of DOCA escape, while a high potassium diet delayed its appearance. The rise of blood pH was facilitated by a low potassium diet and inhibited by a high potassium one. Based on these results, the change in blood pH appears to be one of the factors contributing to the development of DOCA escape.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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