Abstract
1) Serum transfusion from 15 to 55ml was done in 30 cases, and PT, TT and PCT were examined at various interals. A marked shortening of clotting time was seen in 13 of 17 cases with normal coagulability and 11 of 13 cases with abnormal one.
2) In 17 cases with hemorrhagic diathesis a marked clinical effectiveness was seen in 10 cases as follows:
a) Hemorrhage was lessened in bleeding gastric ulcer and essential hematuria in which the PCT was originally within normal range.
b) In 5 of 8 cases of leukemia such favorable effects were seen as decrease of purpura, cease of oozing from the tongue, reduction of capillary fragility, shortening of bleeding tinge and improvement in general malaise. The same effects were seen in a case of severe aplastic anemia.
c) In cases with liver damage and stomach cancer, the prolonged PCT was shortened. In aa case under Warfarin treatment, a temporary shortening of clotting time was induced. In two cases of hemophilia A a marked shortening of PCT was induced by serum transfusion of 25ml.
3) The question why the maximum shortening of the clotting time was not attained immediately after transfusion in some cases and the effect on plasinin activity were discussed.
4) It is concluded that serum transfusion is a useful hemostatic procedure in various hemorrhagic conditions.
