The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 98, Issue 4
Displaying 1-7 of 7 articles from this issue
  • Yoichi Chiba
    1969 Volume 98 Issue 4 Pages 303-327
    Published: 1969
    Released on J-STAGE: November 28, 2008
    1) Serum transfusion from 15 to 55ml was done in 30 cases, and PT, TT and PCT were examined at various interals. A marked shortening of clotting time was seen in 13 of 17 cases with normal coagulability and 11 of 13 cases with abnormal one.
    2) In 17 cases with hemorrhagic diathesis a marked clinical effectiveness was seen in 10 cases as follows:
    a) Hemorrhage was lessened in bleeding gastric ulcer and essential hematuria in which the PCT was originally within normal range.
    b) In 5 of 8 cases of leukemia such favorable effects were seen as decrease of purpura, cease of oozing from the tongue, reduction of capillary fragility, shortening of bleeding tinge and improvement in general malaise. The same effects were seen in a case of severe aplastic anemia.
    c) In cases with liver damage and stomach cancer, the prolonged PCT was shortened. In aa case under Warfarin treatment, a temporary shortening of clotting time was induced. In two cases of hemophilia A a marked shortening of PCT was induced by serum transfusion of 25ml.
    3) The question why the maximum shortening of the clotting time was not attained immediately after transfusion in some cases and the effect on plasinin activity were discussed.
    4) It is concluded that serum transfusion is a useful hemostatic procedure in various hemorrhagic conditions.
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  • Minoru Hirooka, Naoki Kubota, Tadasi Ohno
    1969 Volume 98 Issue 4 Pages 329-343
    Published: 1969
    Released on J-STAGE: November 28, 2008
    Probably a new type of congenital nephropathy associated with hearing loss, ocular abnormalities such as cataracts, excessive myopia, strabismus, chorioretinal degeneration, mental retardation, convulsions and abnormal E.E.G., were observed in a 12-year-old male patient.
    The patient not only had symptoms resembling familial juvenile nephronophthisis such as polyuria and polydipsia since early childhood, growth retardation, choreoretinal degeneration, anemia and azotemia with few abnormalities of urinalysis, but also showed ocular defects and nerve deafness which have been very often observed in Alpert's syndrome. Furthermore, there were mental retardation, convulsions and abnormal E. E. G. which have not been recognized in either of Alport's syndrome and familial juvenile nephronophthisis.
    Histological findings of the kidney obtained by open biopsy revealed various changes of the glomeruli such as thickening of mesangium, increased cellularity, hyalinization, and interstitial and periglomerular fibrosis in some parts. These histological findings were entirely different from those of familial juvenile nephronophthisis and somewhat resembled those of “l'hypoplasie rénal bilatérale avec oligomeganephronie” which was recently described by Royer, Habib and Leclerc.
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  • Takayoshi Toyota
    1969 Volume 98 Issue 4 Pages 345-356
    Published: 1969
    Released on J-STAGE: November 28, 2008
    The diurnal change in plasma immunoreactive insulin level of seventeen diabetic patients was studied before and after the treatment with sulfonylurea. The insulin area was calculated as an index to represent the diurnal summation of plasma insulin. The insulin area of the mild diabetic group and that of the moderately severe group were within a normal range before and after the treatment. The area decreased significantly in the mild diabetic group by the treatment, with a concomitant decrease in the blood glucose. However, the insulin area was unchanged in the moderately severe group. This result may be attributed to an increase of the sensitivity to insulin of the tissues by the treatment in mild diabetic group. In moderately severe group, the plasma free fatty acids (FFA) remained high still after the treatment and this high FFA is thought to be one of the reasons for unchanged plasma insulin level in this group.
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  • Tatsuo Koyanagi, Shin-ichi Hareyama, Ryosuke Kikuchi, Teru Takanohashi ...
    1969 Volume 98 Issue 4 Pages 357-362
    Published: 1969
    Released on J-STAGE: November 28, 2008
    Combined administration of thiamine, riboflavin, pyridoxine, ascorbic acid, nicotinic acid, vitamin A and B12 to 20 students resulted in increase in the concentration of pantothenic acid in serum in 7 students and in decrease in 3 students. Effects of separate administration of thiamine, riboflavin, ascorbic acid or vitamin A on the level of serum pantothenic acid were also examined. It was found that the level could be increased considerably by the administration of thiamine alone. Riboflavin also increased the level but to a lesser extent. Similar patterns of the vitamin effect were also observed for the urinary excretion of pantothenic acid.
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  • Minoru Hirooka, Yakumo Inaba, Tadasi Ohno
    1969 Volume 98 Issue 4 Pages 363-372
    Published: 1969
    Released on J-STAGE: November 28, 2008
    A 10-year-8-month-old girl with the Pickwickian syndrome was presented. In this case, asthmatic bronchitis preceded the development of the Pickwickian syndrome. There was no mental retardation.
    Pulmonary function tests revealed a pattern of hypoventilation: reduction in tidal volume, inspiratory capacity, maximum breathing capacity and timed vital capacity, and increase in functional residual capacity, residual volume and the residual volume/total lung capacity ratio. Further, forced expiratory volume for one second/forced vital capacity, maximal midexpiratory flow, the air velocity index and the expiratory check valve index were also found to be reduced, suggesting the existence of airway obstruction.
    From the clincial symptoms, course and pulmonary function tests of our case, it was assumed that in our case, bronchial obstruction due to asthmatic bronchitis, in combination with malfunction of the respiratory muscles due to obesity, played an important role in the development of the syndrome.
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  • Togo Horiuchi, Kei Koyamada, Hochill Rhee, Takeshi Ishitoya, Tadaaki A ...
    1969 Volume 98 Issue 4 Pages 373-389
    Published: 1969
    Released on J-STAGE: November 28, 2008
    A dye-dilution study was carried out by injecting dye into the right and left atria through the dwelling polyvinyl tubings after open heart surgery and especially after the radical operation for tetralogy of Fallot.
    In every instance time factors in both left and right atrial dye-dilution curves showed marked increase immediately after operation or on the first postoperative day. Subsequently they decreased first rapidly and later gradually. The changes were more marked in the right atrial dye-dilution curves than in the left ones.
    Increase in all the time factors was apparently larger in tetralogy of Fallot than in ventricular or atrial septal defect. Particularly, disappearance time (tpd), time constant of exponential decay of the curve (ts) and mean transit time (_??_R) in the right atrial dye-dilution curves were markedly prolonged and furthermore a remarkable increase occurred in the right heart-pulmonary circulation time (_??_R-_??_L) and right heart-pulmonary blood volume (VRP).
    Cardiac output after the operation was lower in Fallot's tetralogy than in other heart diseases. In two-thirds of the cases of Fallot's tetralogy, however, postoperative cardiac output exceeded 3.0l/min/m2 and attained a normal range.
    The characteristic findings of the dye-dilution curves in tetralogy of Fallot were most closely related to the extent of residual pulmonary stenosis. This was indicated by a large systolic pressure gradient between the right ventricle and the pulmonary artery at the end of open heart correction.
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  • Saburo Matsukura, Akiro Shirota, Masaru Miki, Korenaka Naito, Hiroyuki ...
    1969 Volume 98 Issue 4 Pages 391-402
    Published: 1969
    Released on J-STAGE: November 28, 2008
    Clinical and experimental investigations were performed on the pathophysiology of death in acute intestinal obstruction, and the following results were obtained.
    1) In clinical cases as well as in experimental animals, the number of intestinal coli-group bacilli was remarkably increased in intestinal contents both above and below the obstruction and in ascites. The increase was greatly inhibited by intraintestinal administration of fradiomycin, an unabsorbable antibiotic. Histological changes in other organs were suppressed, and the survival time of dogs was also remarkably prolonged by the treatment.
    2) High molecular substances such as enclotoxin, cellular components or DNA fraction liberated from Escherichia coil were increased in the blood and ascites from patients with acute intestinal obstruction. The increase was fairly well inhibited by the intraintestinal administration of fradiomycin. An intimate relation was consequently assumed between the increase of intestinal microorganisms, especially of coli-group bacilli and the development of clinical symptoms of ileus.
    3) Blood acetylcholine level was extraordinarily elevated in ileus at the time of developing shock-symptoms accompanied by increase of' catecholamine group. The elevation was greatly suppressed by fradiomycin. The change in blood acetylcholine level seemed to be parallel with that in blood concentration of the high molecular substance of E. coli, and a close relationship between them was suggested. The results substantiated the present authors' view that acetylcholine, one of the most important chemical mediators, was responsible for the development of shock-symptoms in ileus.
    4) Comparative examination of inhibitory effects of pyribenzamine (antihistaminics), cyproheptadine (antiserotonin), DV-79 (antiplasmin drug), atropine (anti-acetylcholine) and cortisone (adrenocortical hormone) on ileus symptoms revealed that only atropine, which has a strong anti-acetylcholine activity, could exert a strong preventive effect on the lethal action of the endotoxin and DNA fraction of the E. coli component.
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