Experimental Studies on a New Test for Placental Permeability by Phenolsulfonphthalein Injection to the Fetus (Fetal PSP Test)

Abstract

The authors devised a new diagnostic method of placental permeability by transabdominal injection of PSP into the fetus, and named it ‘fetal PSP test’. In normal full term pregnancy, the excretion of PSP into maternal urine began within 30 minutes after the PSP injection and reached the maximum in 90-120 minutes. The normal value was decided to be more than 16% in total excretion rate for 3 hours. Although the fetal PSP test way considered to be influenced by uterol placental irculation, maternal renal function and other factors of the fetus and mother, a certain parallelism was found between the clinical results and the data obtained from perfusion study by using the delivered placenta.