The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 99, Issue 2
Displaying 1-11 of 11 articles from this issue
  • Hiroshi Shiono, Junichi Kadowaki, Shoichi Kasahara
    1969 Volume 99 Issue 2 Pages 107-113
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The dermatoglyphic analyses of 100 Japanese with Down's syndrome were made in comparison with those of 571 control individuals.
    It appeared that these patients showed characteristic configurations of high frequencies of the characteristics such as the ulnar loop and radial loop on the fourth and fifth digits, high axial triradii (t''), the simian lines, the third interdigital loops, single flexion crease in the fifth digits and the hypothenar patterns.
    There appears to be little difference in frequencies of these characteristic features in Down's syndrome between Japanese and Caucasian patients.
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  • Jun Fujii, Kazuhiko Murata, Hiroshi Yamaguchi, Morio Kuramochi, Akira ...
    1969 Volume 99 Issue 2 Pages 115-119
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Abdominal aorta of the rabbit was constricted with a silver clip above or below the renal arteries. A persistent rise of blood pressure was observed only in rabbits with aortic constriction above the renal arteries. The hypertension did not develop in rabbits with aortic constriction below the renal arteries. Plasma renin activity was within normal limits in 8 rabbits at acute stage of hypertension and was suppressed in 8 rabbits with chronic hypertension. The results indicate that the hypertension following aortic constriction is renal in origin and some renal mechanism not associated with renin-angiotensin system may be involved in it.
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  • Toshio Yoshida, Keiya Tada, Tasuke Konno, Tsuneo Arakawa
    1969 Volume 99 Issue 2 Pages 121-128
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A 10-year-old girl with mental retardation, hyperalaninemia and pyruvicemia was described. Studies on liver biopsy specimens from this patient revealed that pyruvate carboxylase activity was markedly decreased, whereas both pyruvate decarboxylation and glutamic pyruvic transaminase were normal in activity. Furthermore, it was found that an incorporation of pyruvate-2-14C into glycogen in the liver was markedly diminished in the patient as compared with that in a control.
    These findings suggest that the metabolic lesion in the patient with hyper-alaninemia and pyruvicemia is a defective activity of pyruvate carboxylase of the liver, leading to an impaired gluconeogenesis.
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  • Ryoji Oh-i, Morio Kasai, Tohru Takahashi
    1969 Volume 99 Issue 2 Pages 129-149
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The three-dimensional structure of small intrahepatic bile ducts in congenital biliary atresia was examined by graphical reconstruction of serial histological sections. In the disease, intrahepatic bile duct system was constituted by an extremely complex network of proliferating bile ductules. Bile duct proliferation was interpreted as a reaction of the bile system to bile stagnation and bile leakage in the portal area. The restoration of a patent intrahepatic bile system seemed to depend upon the preservation of `main routes' of bile passage, which probably belonged to the pre-existing bile duct system. The maintenance of anatomically recognizable main routes could be correlated with the clinical effect of extrahepatic bile duct plasty.
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  • Katsuhisa Sato
    1969 Volume 99 Issue 2 Pages 151-157
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    N-acetyl-β-galactosaminidase (β-GA) and N-acetyl-β-glucosaminidase (β-GL) were histochemically studied on the cervix of myoma uteri and the cervix of the uterine cervical cancer, both resected immediately after hysterectomia. The results were compared with those of the CPL classification on the same specimen.
    1) Activities of neither β-GA nor β-GL were shown in the normal squamous epithelium and subepithelial tissue, but weak activity of β-GA and moderate activity of β-GL were shown in the columnar epithelial cells. 2) Cells showing the activities of β-GA and β-GL were seen in the parenchyma and adjacent tissue of the cervical cancer. These cells seemed to be mast cell judging from the comparison with the enzyme histochemical staining, H. E. staining and toluidine blue staining with the serial sections. 3) On the number of cancer cells showing the activities of β-GA and β-GL in the cancer tissue, no particular relation was found among the groups in the CPL classification. 4) In the adjacent tissue of cancer, the numbr of cells showing the activity of β-GL was markedly increased in C type of the classification and was moderately increased in CP type. In P type, however, the cells showing the activity of β-GL were not found at all or found scarcely in the preparations. Therefore, the classification by the quantity of the enzyme in the adjacent tissue of cancer was closely related to the CPL classification. The classification by the number of the cells showing the activity of β-GA had also some relation to the CPL classification, but the relation was not so close as that between β-GL and the CPL classification.
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  • Ryuji Yamaguchi, Chuichi Kimura
    1969 Volume 99 Issue 2 Pages 159-164
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The authors devised a new diagnostic method of placental permeability by transabdominal injection of PSP into the fetus, and named it ‘fetal PSP test’. In normal full term pregnancy, the excretion of PSP into maternal urine began within 30 minutes after the PSP injection and reached the maximum in 90-120 minutes. The normal value was decided to be more than 16% in total excretion rate for 3 hours. Although the fetal PSP test way considered to be influenced by uterol placental irculation, maternal renal function and other factors of the fetus and mother, a certain parallelism was found between the clinical results and the data obtained from perfusion study by using the delivered placenta.
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  • Chuichi Kimura, Ryuji Yamaguchi
    1969 Volume 99 Issue 2 Pages 165-170
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The authors studied a clinical value of the fetal PSP test reported in the previous paper. The low level in the fetal PSP test was defined to be below 15% in three-hour excretion rate. The low excretion of PSP was found in about onehalf of the postdate group and of the toxemia group. About 40% of cases with the low excretion rate of PSP showed the low urinary estriol level below 10mg/day by Kambegawa's method. Close relation was recognized between the low value of the PSP test and other several factors concerning the placental permeability; such as the low placental-fetal weight ratio below 0.15, the existence of calcification and white infarct in the placenta, and the histo-pathologic findings of the placenta. Intrauterine fetal distress and neonatal asphyxia were also found more frequently in the group of low PSP excretion than in the normal group. The authors believe that the fetal PSP test is a safe and valuable method in estimating the permeability funetion of the placenta of late pregnancy.
    1. The authors devised a method to examine permeability function of the placenta by injection of PSP into the fetus. The normal excretion rate in maternal urine was defined to be more than 16% per three hours.
    2. The coincidence rate between the fetal PSP test and the urinary estriol was about 42%.
    3. Close relation was recognized among the result of the fetal PSP test, histologic findings of the placenta, such as calcification, infarct and other histologic findings, and placental-fetal weight ratio.
    4. Intrauterine fetal distress in partu and neonatal asphyxia were found more frequently in the group of low PSP excretion.
    5. Low PSP excretion below 15% per three hours was found in 57% of cases with prolonged pregnancy and in 52% of cases with toxemia of pregnancy.
    6. The authors believe that the fetal PSP test is a simple and safe test for permeability function of the placenta.
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  • Masashi Nakamura, Saburo Usutani, Takahisa Horimai, Kazuo Sugawara
    1969 Volume 99 Issue 2 Pages 171-178
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The basal metabolic rate (BMR) was determined in 9 light workers (clerical workers) and 9 heavy workers (railway linemen) in the north-eastern snowy region. In general, the basal metabolic rate was high in winter and low in summer, as reported by previous investigators. However, a characteristic lowering of BMR in the severe cold snowy season and rising in spring were also observed. This lowering has not been reported in Japan, so far as is known. The BMR of the physical workers might be influenced by the grade of their performance; it lowers along with the decrease of work in the snow season, and rises along with heavy work in summer. Thus, it seems possible that heavy physical work changes the pattern of seasonal variation in BVIR.
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  • Toshiro Sakurada, Shintaro Saito, Kiyoshi Inagaki, Sumio Tayama, Tatsu ...
    1969 Volume 99 Issue 2 Pages 179-188
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A new method for the quantitative determination of free triiodothyronine (fT3) and an accurate method for the quantitative determination of free thyroxine (fT4) in human plasma were developed.
    The percentages of T3 and T4 in plasma were studied by thin-layer chromato-graphy. An elutable fraction (EF) of T3, ratio of free 125I-T3 to protein-bound 125I-T3, was obtained using Sephadex-microcolumn chromatography. EF of T4 was obtained by the same method.
    Mean normal total T3 (tT3) and total T4 (tT4), calculated from plasma butanol-extractable iodine (BET) and molar percentages of T3 and T4, were 0. 63 and 5. 59μg per 100ml plasma, respectively.
    Mean normal fT3 and fT4, calculated from tT3, tT4 and EF values of T3 and T4, were 2.43 and 2.21mμg per 100ml plasma, respectively.
    The fT3 values can be obtained by the present method more easily and speedily than by the method of Nauman et al. The present fT4 values, in consideration of BET and the percentage of T4 in plasma, represent a more accurate one than the earlier data by Lee et al.
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  • Toshiyuki Ando, William L. Nyhan
    1969 Volume 99 Issue 2 Pages 189-195
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The excretion of the aminoketones, aminoacetone (AA) and 5-aminolevulinic acid (ALA) has been studied in 7 children. One of the children had ketotic hyperglycinemia and one had nonketotic hyperglycinemia. The formation of these aminoketones has been studied in vivo using 14C-labeled glycine and threonine.
    The amounts of AA in the urine were slightly smaller than those of ALA in the subjects studied. Neither was increased by the infusion of large amounts of glycine. The amounts of aminoketone were independent of the concentrations of glycine in the plasma and did not differ from control in patients with disordered glycine metabolism. The amounts of aminoketone excreted varied directly with the weight of the child.
    The injection of labeled glycine did not yield labeled urinary AA but small amounts of labeled ALA were found. Significant labeling of urinary AA was found after the administration of labeled threonine.
    It is concluded that the metabolic precursor of urinary AA is threonine. Conversion to aminoketones, either AA or ALA, is not a major catabolic pathway for glycine in man. These pathways are not involved in either the etiology or the adaptation to hyperglycinemia.
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  • Takao Fukuda
    1969 Volume 99 Issue 2 Pages 197-206
    Published: 1969
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Two cases of particular neoplastic reticulosis of splenic origin were reported. Neoplastic reticulum cells were exclusively proliferated in the Billroth's cords (Case 1) or in the follicles (Case 2) of the spleen and showed the features of diffuse interstitial infiltration and hematogenous dissemination, which indicated leukemia-like process in this disease.
    The reticulum cells in other organs, such as the lymph nodes and bone marrow, showed no tendency to proliferation. No feature of the usual leukemia was demonstrated.
    Leukemia-like proliferation of reticulum cells may originate from various organs and tissues of the reticuloendothelial system, and such a condition is most appropriately called malignant reticulosis with or without hematological findings.
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