Splenogenous Malignant Reticulosis

Abstract

Two cases of particular neoplastic reticulosis of splenic origin were reported. Neoplastic reticulum cells were exclusively proliferated in the Billroth's cords (Case 1) or in the follicles (Case 2) of the spleen and showed the features of diffuse interstitial infiltration and hematogenous dissemination, which indicated leukemia-like process in this disease.
The reticulum cells in other organs, such as the lymph nodes and bone marrow, showed no tendency to proliferation. No feature of the usual leukemia was demonstrated.
Leukemia-like proliferation of reticulum cells may originate from various organs and tissues of the reticuloendothelial system, and such a condition is most appropriately called malignant reticulosis with or without hematological findings.