糖尿病患者の早朝空腹時血漿cAMP

抄録

Fasting plasma adenosine 3', 5'-monophosphate (cAMP) levels in diabetics without ketoacidosis were measured, and the relationships between the fasting plasma cAMP levels and fasting blood glucose (FBS), plasma immunoreactive glucagon (IRG), mode of therapy, onset and duration of diabetes mellitus were investigated.
There was no correlation between plasma cAMP levels and FBS, plasma IRG, onset and duration of diabetes mellitus. No significant difference in fasting plasma cAMP levels was found among diet-, drug-, insulin-treated diabetics and control subjects.
The fasting plasma cAMP levels in insulin-treated diabetics whose onset was before 39 years old, were significantly lower than those in control subjects. This finding is in agreement with the studies of other investigators.