Fasting plasma adenosine 3', 5'-monophosphate (cAMP) levels in diabetics without ketoacidosis were measured, and the relationships between the fasting plasma cAMP levels and fasting blood glucose (FBS), plasma immunoreactive glucagon (IRG), mode of therapy, onset and duration of diabetes mellitus were investigated. There was no correlation between plasma cAMP levels and FBS, plasma IRG, onset and duration of diabetes mellitus. No significant difference in fasting plasma cAMP levels was found among diet-, drug-, insulin-treated diabetics and control subjects. The fasting plasma cAMP levels in insulin-treated diabetics whose onset was before 39 years old, were significantly lower than those in control subjects. This finding is in agreement with the studies of other investigators.
The reliability of a “HemascopeTM System” was tested using venous blood samples obtained from diabetics. The following results were obtained. 1) The blood sugar levels determined with this system were significantly correlated to those obtained with an Autoanalyzer (r=0.93, p<0.001). 2) The influence of time of exposure to the blood sample on the blood sugar values was also studied. In order to obtain exact blood sugar values, it was necessary for the exposure time to be just for 60 sec. 3) The blood glucose levels determined with this system gradually declined after washing out a strip. However, the decline in blood sugar values was not significant when they were measured within 20 sec after washing out the strip. It is concluded that the “HemascopeTM System” represents a simple and reliable method for the measurement of blood glucose levels if the procedure is performed accurately.