抄録
It is well known that glycosylated hemoglobin, designated as hemoglobin AI (HbAI), can provide useful information regarding logn-term blood glucose control in diabetic patients.
It is well known that glycosylated hemoglobin, designated as hemoglobin AI (HbAI), can provide useful information regarding logn-term blood glucose control in diabetic patients.
Red blood cells from normal adults were incubated in a medium with a high-glucose concentration. The HbAIc concentration showed an increase of 141% at 7 days and 146% at 9 days after incubation compared to the starting level. After 7 days of incubation, the red blood cells were transferred to the medium without glucose and incubated for a further 2 days. The concentration of HbAIc decreased rapidly, reaching 114% compared to the starting level after 2 days.
The above findings indicate that part of HbAI forms an unstable linkage as well as a Schiff base compound and fluctuates with rapid changes in blood glucose concentration. Clearly, detailed observations for rapid changes of HbAI concentration should be made in the future.
