抄録
To clarify the mechanism by which intra-abdominal fat accumulated, we examined the influence of sex hormones on fat distribution and glucose intolerance in genetically obese-hyperglycemic OLETF rats, which are characterized by mesenteric fat accumulation. Male and female OLETF rats aged 5 weeks were orchiectomized and ovariectomized, respectively, and followed together with sham-operated control male and female OLETF rats until 35 weeks of age. At the age of 35 weeks, an oral glucose tolerance test (OGTT) showed a significant decrease in plasma glucose levels in the orchiectomized group compared with those in control group. There were no significant differences in insulin response during the OGTT between the orchiectomized and control groups. Although the mesenteric (M) and subcutaneous (S) fat weight in orchiectomized group significantly incressed compared to the control group, the increase in S fat weight was more marked than in M fat weight, and the M/S fat weight ratio in orchiectomized group decreased significantly compared to the control group.
In contrast, there were no significant differences in glucose tolerance, insulin response during OGTT or fat distribution between the ovariectomized and controlgroups.
