Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Short Communications
Environmental Effect on Eosinophilic Granulomatous Pneumonia (EGP) in Brown Norway Rats
Ryoichi OhtsukaKunio Doi
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2003 年 16 巻 2 号 p. 129-131

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The prevalence of eosinophilic granulomatous pneumonia (EGP) is well known in Brown Norway (BN) rats. In this study, age-related changes in the incidence and severity of EGP in 4 to 20 weeks old BN rats were examined under two different housing conditions (isolator cages without woodchips and common cages with woodchips for bedding) in a SPF animal room in Charles River Japan Inc. A routine microbiological survey gave negative results to any specific pathogens tested. As a result of histopathological examination, there were no lung lesions observed at the age of 4 weeks. EGP developed at and after the age of 7 weeks, but the incidence and severity of EGP showed no age-related changes under both housing conditions. These findings suggest that EGP in BN rats may be a hypersensitivity response of strain-specific nature as reported by Albers and Clifford.
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© 2003 The Japanese Society of Toxicologic Pathology
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