Morphological Changes of Mitochondria in the Hepatocytes Induced by Administration of a Large Amount of Di (2-ethylhexyl) phthalate (DEHP) to Cynomolgus Monkeys (Macaca fascicularis)

Shigeru Satake; Youhei Tanigawa; Hiroshi Maeda; Yasuhiro Kamimura; Yutaka Chihaya; Hiroaki Miyajima; Masanobu Goryo; Kosuke Okada

doi:10.1293/tox.21.73

Short Communication

Morphological Changes of Mitochondria in the Hepatocytes Induced by Administration of a Large Amount of Di (2-ethylhexyl) phthalate (DEHP) to Cynomolgus Monkeys (Macaca fascicularis)

Shigeru Satake, Youhei Tanigawa, Hiroshi Maeda, Yasuhiro Kamimura, Yutaka Chihaya, Hiroaki Miyajima, Masanobu Goryo, Kosuke Okada

著者情報

キーワード: Di (2-ethylhexyl) phthalate (DEHP), cynomolgus monkey, hepatocyte, mitochondria, peroxisome

ジャーナルフリー

2008 年 21 巻 1 号 p. 73-75

DOI https://doi.org/10.1293/tox.21.73

詳細

抄録

The purpose of this study was to determine the relation between administration of a large amount of Di (2-ethylhexyl) phthalate (DEHP) and peroxisome proliferation in cynomolgus monkey (Macaca fascicularis) hepatocytes. DEHP was administered orally to four cynomolgus monkeys, once daily for 28 days at dose levels of 1,000 and 2,500 mg/kg/day. Enlargement of the mitochondria, and lamellar orientation of the cristae along the major axis of the mitochondria were observed in the hepatocytes; however, we did not observe clear proliferation of peroxisomes.

責任著者(Corresponding author)

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