Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Case Reports
Porencephaly in a Cynomolgus Monkey (Macaca Fascicularis)
Chika HirowatariRinya KodamaYuji SasakiYohei TanigawaJunko FujishimaTsuyoshi YoshikawaKaori YabuuchiYuki KuwamuraKimiaki HirakawaYasuhiro KamimuraHiroshi Maeda
著者情報
キーワード: brain, cynomolgus monkey, porencephaly
ジャーナル フリー

2012 年 25 巻 1 号 p. 45-49

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抄録

Porencephaly was observed in a female cynomolgus monkey (Macaca fascicularis) aged 5 years and 7 months. The cerebral hemisphere exhibited diffuse brownish excavation with partial defects of the full thickness of the hemispheric wall, and it constituted open channels between the lateral ventricular system and arachnoid space. In addition, the bilateral occipital lobe was slightly atrophied. Histopathologically, fibrous gliosis was spread out around the excavation area and its periphery. In the roof tissue over the cavity, small round cells were arranged in the laminae. They seemed to be neural or glial precursor cells because they were positive for Musashi 1 and negative for NeuN and GFAP. In the area of fibrous gliosis, hemosiderin or lipofuscin were deposited in the macrophages, and activated astroglias were observed extensively around the excavation area.

著者関連情報
© 2012 The Japanese Society of Toxicologic Pathology
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