抄録
Hepatocyte-like cells were observed in the stomach of one female and one male B6C3F1 mice. Gastric hepatocytes in the glandular stomach of a female mouse were observed in adenocarcinoma as same as reported previously. However, the male mouse showed gastric hepatocytes adjacent to the dysplastic gastric epithelium of the glandular stomach. These cells have the histological, ultrastructural and immunohistochemical characteristics resembling those of normal hepatocytes. Since alpha-fetoprotein was also demonstrated in these cells, a comparison with alpha-fetoprotein-producing gastric adenocar-cinoma which develops in humans was attempted. However, the paucity of neoplastic nature of these hepatocyte-like cells suggested that they were metaplastic in origin similarly to the pancreatic hepatocytes.
