抄録
Thrombosis is easily formed in a stagnated bloodstream in the left atrium, and it frequently is a cause of cardioembolic stroke. We found that some of the SPORTS (Spontaneously-Running-Tokushima-Shikoku) rats died after losing body weight after the age of one year. At autopsy, formation of thrombi in the left atrium was recognized in SPORTS rats. The objective of this study was to clarify the autopsy results in the SPORTS rats related to thrombus formation in the left atrium. The incidences of atrial organized thrombosis were 57% in male SPORTS rats and 38% in female SPORTS rats. Systolic blood pressures were 134 ± 16 mmHg (control rats 115 ± 11 mmHg) and heart rates were 459 ± 21 beat/min in male SPORTS rats. Arrhythmias, such as atrial fibrillation, were not recognized by electrocardiogram in SPORTS rats.
We established a line labeled SPORTS rats that form spontaneous thrombi in the left atrium. The SPORTS rat is a new model leading to a high incidence of thrombus formation in the left atrium and may contribute to development of new anti-thrombotic approaches for human atrial thrombosis.
