抄録
Perfluorohexanoate [PFHx, F(CF2)5COO-] was evaluated in acute, fish, early life stage toxicity test, toxicokinetics, 24-month oral combined chronic toxicity/carcinogenicity study, combined developmental and perinatal/postnatal reproduction oral toxicity study and Po/w studies. The NOEC and LOEC for hatching success, post-hatch larval survival, total fish length and fish weight were 10 and >10 mg/L respectively. Excretion patterns and rates of ammonium perfluorohexanoate (APFHx) after administration of a single and multiple (14 days) oral dose(s) at 50 mg/kg to male and female mice and rats were examined. After a single oral administration and the multiple dose tests, total excretion was rapid, irrespective of gender or species. The NOEL for neoplastic findings was determined to be 100 mg/kg/day (males), 200 mg/kg/day (females) (the highest dosages examined and the previously determined MTD). The NOEL for non-neoplastic systemic toxicity was observed to be 15 mg/kg/day for male rats and 30 mg/kg/day for female rats. Under the conditions PFHx is not carcinogenic in rats and its chronic toxicity was low. The results in the perinatal/postnatal reproduction study and indicate a very minimal effect of PFHx at 100 mg/kg/day with a clear NOEL at 35 mg/kg/day. On the basis of these data from this study, the maternal NOEL for PFHx is 100 mg/kg/day. The NOAEL in the F1 generation is 100 mg/kg/day. None of the effects observed in the pups preweaning persisted into the postweaning period.
