抄録
Breast cancer is one of the most common cancers in the world, and its occurrence has been increasing in recent years. Although surgical resection and chemotherapy are common options for carcinoma, surgery is the treatment choice for only the small fraction of patients with localized disease. While Cytotoxic chemotherapy agents are minimally effective at improving patient survival, chemotherapy drugs can damage normal cells. Thus, it is very important to find a new agent for cancer treatment. Lantana camara L. is a species of flowering plant in the verbena family. Verbenaceae is native to the American tropics. Until now, there is no study on the antitumor effect of Lantana camara L.. To find the antitumor effect Lantana camara L., the anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with apoptosis. Lantana camara L. have the effect of anti proliferation with IC50 value of 63.90 μg/mL. It induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis activation. These finding suggest that Lantana camara L. should be useful as a chemotherapeutic agent for breast cancer patients.
