主催: 日本毒性学会
Ginseng is traditional medicinal herb for physical strength, digestive organs, nervous system, metabolic system and circulatory system. Black ginseng is produced from ginseng by nine repeated steaming-drying cycles. The pharmacological and biological activities of black ginseng are believed to be better than those of ginseng or red ginseng. Red ginseng is the most commonly used health functional food in Korea and its functionality was demonstrated through many studies, while black ginseng is little reported on its functionality scientifically. Therefore we tested the prevention effect of acute hepatitis induced by CCl4 for 10-day oral-repeated trial of black ginseng in male Sprague-Dawley rats (0, 1, 3, 10 ml/kg/half day). Hepatotoxicity was induced by CCl4 (1 ml/kg, ip) and positive control was treated with silymarin (100 mg/kg, po). After administration of black ginseng, serum alkaline phosphatase (ALP), alanine aminotransferas (ALT), aspatate aminotransferase (AST), total bilirubin (T-Bil), gamma-glutamyl transferase (γ-GTP) and hepatic histopathologies were examined. Urinary metabolite profiles were obtained by 1H NMR analysis. Serum enzymes and hepatic histopathologies showed dose-dependent protective effects of black ginseng. Urinary metabolomics profiles might provide mechanistic insight of black ginseng. These results suggest that black ginseng might use for prevention of acute hepatitis.
