抄録
2,5-hexanedione is the metabolic end product of n-hexane, which is an organic solvent that has been known to alter different reproductive functions in mammals. The aim of this study was to determine the effects of 2,5-hexanedione on reproductive functions in mouse, especially the maturation of mouse oocytes. We observed that extrusion of the first polar body in mouse oocytes were significantly inhibited by 2,5-hexanedione. Furthermore, mitochondrial membrane potentials (ΔΨm) were also altered in mouse oocytes, leading to apoptosis of the oocytes. Our results suggest that the 2,5-hexanedione might have affected the maturation of oocytes causing the ΔΨm to alter leading to apoptosis which maybe one of the most important mechanisms.
