IEICE Transactions on Electronics
Online ISSN : 1745-1353
Print ISSN : 0916-8524
Special Section on Analog Circuits and Their Application Technologies
A Current-Integration-Based CMOS Amperometric Sensor with 1024 × 1024 Bacteria-Sized Microelectrode Array for High-Sensitivity Bacteria Counting
Kohei GAMOKazuo NAKAZATOKiichi NIITSU
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2017 Volume E100.C Issue 6 Pages 602-606

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Abstract

CMOS amperometric sensors with a microelectrode array offer great potential for counting bacteria because of their low cost, compact size, and ease of use. This paper presents a current-integration-based CMOS amperometric sensor for high-sensitivity bacteria counting. It has a current integrator for noise reduction and reportedly the most large-scale microelectrode array (1024 × 1024). This proposed sensor can count the number of bacteria ranging from a single cell to approximately a million cells. A prototype chip was fabricated using two-poly three-metal (2P3M) 0.6-µm standard CMOS technology. A 7.6 × 7.1-mm2 chip operates from a 5V supply at 1.9mA. In addition, by using the prototype chip, we performed electrochemical measurement and partial 2D imaging of silicone through constant potential amperometry. The measurement results indicate that the proposed sensor chip was able to accurately readout redox current from the 1024 × 1024 sensor array.

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© 2017 The Institute of Electronics, Information and Communication Engineers
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