Abstract
The physiological action of glutamylcholine, synthesized by Nishizawa as a therapeutic agent for poliomyelitis, was studied. The action of glutamylcholine was compared with that of acetylcholine. In experiments with the Magnus method, (using rat intestine, the effect of the former was only 1/200 of that of the latter, and it was 1/10 in the effect on the blood pressure when injected intravenously. When injected intrathecally in rabbits and the bood pressure measured, glutamylcholine not only showed the same effect as acetylcholine, but the duration of the effect was several times longer. There is no irritating effect when injected intraspinally in human subjects. Injection of more than 30mg/kg intravenously in guinea pigs results in death but rabbits do not die with this dosage.
