STUDIES ON THE SIGNIFICANCE OF THE ALKALINE PHOSPHATASE IN RICKETS : (II) THE EFFECT OF VITAMIN D ON THE ALKALINE PHOSPHATASE ACTIVITY OF SERUM AND ORGANS

Abstract

The prophylaxis and therapy of the rickets of albino rats were studied with different dosages of vitamin D (50,100 and 200 I.U. per week per os). The effect of vitamin D was estimated by alkaline phosphatase activities in the serum, bone, kidney and intestine. In the prophylactic experiment, it could be fund a parallelism between the doses of vitamin D and the alkaline phosphatase activities in the serum or the bone, especially in the latter the phosphatase activities were inversely proportional to the logarithms of the doses of vitamin D. But such relations could not be found in therapeutic experiments. In both experiments, the variation of the alkaline phosphatase activity of serum seemed to have no correlation with that in the kidney and intestine.