STUDIES ON VITAMIN B_6 METABOLISM : (II) INFLUENCE OF THE ADMINISTRATTON OF VARIOUS ANTIBIOTICS UPON THE AMOUNTS OF URINARY VITAMIN B_6 IN NORMAL RABBIT

Abstract

Pyridoxine + pyridoxamine, pyridoxal and 4-pyridoxic acid were determined in 24 hour urine after the administration of aureomycin, terramycin or homosulfamine for healthy rabbits. In animals which were given aureomycin or terramycin, both pyridoxine + pyridoxamine and pyridoxal were apparently decreased after their administration, and remarkable change was recognized in 4-pyridoxic acid excretion. In several animals, pyridoxic acid pronouncedly decreased immediately after the administration and maintained its level and in others, it once decreased then increased to normal level and after 10-13 days it again decreased. In anima1s which were given homosulfamine, no marked change was seen except a slight increase in pyridoxal excretion.