STUDIES ON MECHANISM OF THIAMINE ABSORPTION : (I) LOADING TEST OF THIAMINE

Abstract

Even though oral dose of thiamine exceeded 10 mg, the urinary excretion of the vitamin showed no further increase than when the dose was 10 mg. On the contrary, the fecal excretion of thiamine showed a noticeable increase as oral dose of the vitamin became higher, particularly when it exceeded 10 mg. The thiamine content of blood showed only a slight increase after oral administration of the vitamin even if a large amount of the vitamin was administered. On the other hand, after subcutaneous injection of thiamine, its blood content showed a remarkable increase proportionally to the quantity of administration, having a tendency to fall rapidly to the original level.