PHARMACOLOGICAL ACTIONS OF DIPHOSPHOPYRIDINENUCLEOTIDE : (I) EFFECTS OF DIPHOSPHOPYRIDINENUCLEOTIDE ON PERIPHERAL VESSELS, CARDIAC SYSTOLE AND BLOOD PRESSURE

Abstract

The pharmacological actions of diphosphopyridinenucleotide (DPN) on peripheral vessels, cardiac systole and blood pressure were studied. It was found that DPN induced a slight contraction of peripheral vessels, but inhibited cardiac systole and brought about a decrease of blood pressure. These actions were also observed when adenosine was used in place of DPN. Atropine and pyribenzamine had no influence on the actions of adenosine or DPN on cardiac systole and blood pressure.