諸疾患時におけるビオチン代謝 : (I)諸疾患患者の尿中ビオチン排泄量

抄録

Spontaneous excretion of biotin was found to be increased in patients with liver diseases and diabetes mellitus, while it was found to be decreased in patients with gastrointestinal diseases, hypertension, chronic nephritis, and those who were treated with aureomycin. Increase in urinary excretion following intramuscular administration of biotin was greater in patients with liver diseases, especially acute hepatitis, and in diabetes mellitus. In patients with hypertension, chronic nephritis, and those who were treated with aureomycin, increase in urinary biotin excretion was less than normal. This data indicates that there may be disturbances in biotin utilization in liver diseases and diabetes mellitus, while biotin deficiency seems to exist in patients treated with aureomycin. Signigicant correlation was fond between the fasting blood sugar level and the increase of urinary excretion after biotin administration in patients with diabetes mellitus. Normalization of biotin metabolism was observed after insulin treatment.