Niemann-Pick C1-like 1 (NPC1L1) is essential for the intestinal absorption of cholesterol and is recognized as a pharmacological target of ezetimibe, a cholesterol absorption inhibitor clinically used for the treatment of dyslipidemia. Based on the hypothesis that some lipophilic molecules may be taken up in the intestinal lumen via a pathway shared with cholesterol, we tested some fat-soluble molecules and obtained the data suggesting that NPC1L1 has an ability to transport vitamin E and vitamin K, and that ezetimibe is able to inhibit the intestinal absorption of these fat-soluble vitamins. In addition, drug-drug interaction between ezetimibe and warfarin could be accounted for by the decreased vitamin K absorption. This review article describes the basis and recent topics of NPC1L1 and, especially, its relationship with vitamin transport.
This present report aimed to confirm the change in L-carnitine supply following the change of feedstuff in the formula feed for poultry. The feedstuff of formula feed has been changed in accordance with the change of the cost of formula feed, active utilization of organic residue substances and/or the safety of the substances under the relating lows. During the past about 20 years, as a boundary 2001 when bovine spongiform encephalopathy happened in Japan, utilization of animal feedstuff showed a dramatic reduction to about 2% from 8.8% in the mean level of poultry formula feed. L-Carnitine supply is highly dependent on the animal feedstuff. Therefore, it seemed that L-carnitine supply in the poultry formula feed was reduced to nearly quater level in the same manner.