TOXOPYRIMIDINE群物質の研究 : (VI)脳TRANSAMINASEとGLUTAMIC DECARBOXYLASEにおよぼす影響

抄録

The effect of 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP) and hydroxylamine on the enzymic system related to glutamic acid metabolism in the brain and involving vitamin B_6,that is, glutamic decarboxylase and glutamic-aspartic transaminase was studied. It was found that when a running fit is induced by OMP, the OMP is phosphorylated in the body and inhibits glutamic-aspartic transaminase but this enzyme system is not affected by hydroxylamine. Glutamic decarboxylase, on the other hand, is inhibited by both OMP and hydroxylamine and this inhibition takes place prior to the onset of the running fit. It is suggested that the inhibition of glutamic decarboxylase plays an important role in the inducement of the running fit.