抄録
Thiamine tetrahydrofurfuryl disulfide (TTFD), a new analogue of allithiamine, was studied on its several biological activities comparing with thiamine and thiamine propyl disulfide (TPD). TTFD showd equivalent curative activity as thiamine in the rat growth assay. TTFD, when administered intravenously to rabbits caused a marked elevation of blood thiamine level, especially in the blood cells, and sustained this high level. The results of toxicity tested by intraperitoneal and oral routes, suggested the better gastrointestinal absorption of TTFD than that of thiamine hydrochloride. Local irritability of TTFD was neglisible compared with that of TPD.
