Abstract
The present study was undertaken in an attempt to estimate the interrelationship between riboflavin content of liver, bile and blood under some pathological conditions. Following intravenous administration of riboflavin, lower liver and bile riboflavin levels were observed in gastric cancer than in others without hepatic disturbances, thereby hepatic FAD fraction rather decreased and blood riboflavin level in mesenteric and peripheral veins increased only slightly in gastric cancer. In rabbit experiment, when CCl_4,was ingested, intravenously administered riboflavin was excreted in smaller amount into bile with simultaneous lower level of hepatic riboflavin in total and in FAD fraction depending upon the degree of liver affection, and moreover riboflavin level was higher in portal blood than in peripheral blood. These seem to be the most probable explanation of the disorder of riboflavin uptake and FAD synthesis in liver and reduced excretion in bile when hepatic damage exists.
