Abstract
Investigations were made on the changes of vitamin B_6- and pyridoxal phosphate contents in the tissues of vitamin B_6 deficient rats and of animals administered with antivitamins. In case of vitamin B_6 deficiency, the decrease of vitamin B_6 contents became significant in the following order : heart, brain, liver, kidney, muscle, spleen, and testicle. Vitamin B_6 contents were the lowest after 6-8 weeks on a deficient diet. The deficient state was nearly recovered to normal after two weeks administration of vitamin B_6. The experiment with antivitamin bore a resemblance to that of vitamin B_6 dificiency. It was considered that the more important the organ in the body was, the less the decrease in vitamin B_6 content was and it might suggest the importance of each organ in the metabolism.
