Abstract
During the last few years, we have been studying on the antibody formation in vitamin B_6 deficiency. For the purpose of studying the mechanism of its diminution, in this paper, the author examined the function of the reticuloendotherial system, the cell reaction in local lymph nodes, the protein synthesis and the secondary reaction in sensitized vitamin B_6 deficient rats. The atrophy of the lymphatic tissue and inhibition of its mitosis and cell reaction to the antigen were found. Moreover, it was found no diminution in the secondary response in spite of such changes in the primary response.