抄録
It is well known that thiamine hydrochloride is unstable in the presence of calcium carbonate or ascorbic acid. The authors synthesized three kinds of stable salt of thiamine, namely thiamine di-diphenyl monosulfonate, dithiamine diphenyl-4,4'-disulfonate and thiamine diphenyldisulfonate. They are difficult soluble in water, tasteless, odorless, non-toxic and stable even in the presence of calcium carbonate. Dithiamine diphenyl-4,4'-disulfonate is easily absorbed from digestive tract and blood thiamine concentration is maintained higher level for a long time than thiamine hydrochloride, so that the salt may be well used for the treatment of latent beriberi.
