PATHOLOGICAL STUDY ON RIBOFLAVIN DEFICIENCY DISEASE

Abstract

The author examined the changes of each organs of rat which fed with riboflavin deficient diet, histologically and histochemically. On animals of ariboflavinosis, it was showed remarkable degeneration of main organs, fatty degeneration of liver, degeneration and atrophy of nerve cells, degeneration of heart muscles and kidneys etc., except eye and skin lesions. From ultraviolet microscopical pictures of liver cells and intestinal epithelium etc., the author concluded that the disturbances of nucleic acid and protein synthesis in cells play the important role in pathogenesis of ariboflavinosis.