ON THE EFFECT OF OROTIC ACID ON EHRLICH'S ASCITES TUMOR CELLS

Abstract

The author observed the effect of orotic acid on Ehrlich's ascites tumor cells. After intraperitoneal transplantation of ascites tumor cells (1×10^6), orotic acid injection was performed for 6 days. More than 128 mg/kg per day of orotic acid, was toxic for mice. By an administration of 4-64 mg per kg per day carcinoma cells increased. The hypertrophy of nucleolus caused by orotic acid was found by phase contrast microscope, showing the intensive absorbtion at 265mμ. The hypertrophical nucleolus was more pyroninphilic by methylgreen. pyronin stainning, suggesting the increase of RNA. It was concluded that orotic acid may promote the cell division.