抄録
The amount of pantothenic acid which appeared in the urine of the rat after the oral and intraperitoneal administration of D-pantothenol or calcium D-pantothenate were determined by means of microbiological assay with Lactobacillus arabinosus. The amount of pantothenic acid excreted in the urine within 24 hours after intraperitoneal injection of D-pantothenate to the rat was larger than that of D-pantothenol injection. However, the total amount of pantothenic acid excreted in the urine during a week after the administration was exactly the same in both cases. It suggests that the utilization of D-pantothenol in vivo continues longer than of D-pantothenic acid. On the contrary, the amount of pantothenic acid excreted in the urine within 24 hours after the oral administration of D-pantothenol was larger than that of D-pantothenate. This fact may show that the absorption rate of D-pantothenol from the intestine is more rapid than that of the D-pantothenate. Above results suggest that the utilization of D-pantothenol when used as a pharmaceutics in vivo is higher than that of calcium D-pantothenate.
