抄録
The absorption of orally administered vitamin B_<12>-^<60>Co was decreased after hypophysectomy or adrenalectomy, giving 47.7±2.8 and 52.5±3.3%, respectively, as compared with 66.4±4.6% in controls. These decreases could not be corrected with intrinsic factor. The decrease in adrenalectomized rats could be corrected with corticosterone, but that in hypophysectomized with simultaneous administration of intrinsic factor and ACTH. In hyperadrenocortical state, there were no remarkable differences. The intestinal excretion of radioacitvity following subcutaneous administration of B_<12>-^<60>Co did not change definitely. The urinary excretion of radioactivity was correlated with intestinal absorption at oral administration test, but in the byperadrenocortical state it showed a tendency to increase. No hormonal effect, however, was seen upon the hepatic uptake of B_<12>-^<60>Co. The renal uptake did not show any change by hypophysectomy or adrenalectomy, but increased by corticosterone loading test. It can be concluded that, the intestinal absorption as well as the metabolism of vitamin B_<12> in vivo is disturbed by adrenalectomy or hypophysectomy, and these disturbances can be corrected with either the administration of corticosterone or co-administration of intrinsic factor with ACTH. It is suggested that the disturbance in hypophsectomized rats may be due to the loss of adrenocortical function.
