STUDIES ON THE ORAL ADMINISTRATION OF LARGE AMOUNTS OF THIAMINE TO MEN

Abstract

Thiamine propyldisulfide (TPD) equivalent to 400 mg of thiamine hydrochloride was orally administered in the forms of two pills to four healthy young men just after a breakfast for consecutive 4 days. The 3.5 and 3.5〜24 hours urines after taking the pills were collected and determined the contents of thiamine and riboflavin in these urine samples and compared with those values of the urine samples from the subjects at the control period without having the pills. It was observed that average amount of thiamine excreted in urine per person per day were 96.9 mg when TPD were given. The percentage of thiamine excreted to the amounts administered was 24%, and this percentage was similar to that of the control period when only 1.1 mg of thiamine were taken from the test diet. It was also observed that the urinary excretion of riboflavin was not increased when TPD was orally given to the subjects. Apparent absorption percentages of thiamine from 400mg of TPD and 1.1mg of thiamine from the foods were not much different.