ENZYMATIC STUDIES ON THE EFFECT OF ANTIBIOTICS ON THIAMINE METABOLISM : (III) EFFECT OF ANTIBIOTICS UPON THE PHOSPHORYLATION ON THIAMINE IN THE RAT LIVER, IN VIVO

Abstract

The phosphorylating and dephosphorylating activities of thiamine in the mitochondria and supernatant of the rat liver, orally administered with a large or small quantities of Aureomycin were discussed. The phosphorylating activity of thiamine in the mitochondria and supernatant did not change by the quantity of Aureomycin. The dephosphorylating activity of esterified thiamine in the liver supernatant did not change in the second week, but the activity increased slightly in the fourth week of the Aureomycin administration.