Abstract
Riboflavin in the blood is found mainly in the blood cells as esterified form. The content of esterified riboflavin in the blood cells is low in the majority of various diseases. Mass administration of free riboflavin results an increase of total riboflavin (mainly, the free type) in the blood up to 15μg/dl. One to two third of the orally administered dosis and three forth of intravenously adminstered dosis are excreted into the urine. Daily administration of 20 to 40 mg of ATP accelerates the esterification of riboflavin in the blood. Mass administration of thiamine or its derivatives (50-100mg per day) decreases the riboflavin content of blood within one to two weeks. However, addition of riboflavin as much as 10% of administered dosis of thiamine prevents the decrease of riboflavin content and increases the esterified form.
