抄録
In the course of study on the biological effect of AICA, it was recognized that the pyruvate decarboxylation by yeast apocarboxylase and cocarboxylase system was accelerated by addition of AICA to the reaction system. This effect was not observed in the yeast carboxylase extracted without cocarboxylase elimination. It was shown that this effect was different from the mechanism of Ochoa's effect based on thiamine addition and of the prevention of heavy metal inhibition. The effect of AICA is supposed to be concerned in the formation of apo- and coenzyme complex.
