抄録
No difference between the blood lipoic acid level of rabbit after oral administration of TATD and lipoic acid was found, differing from thiamine level in the blood. On the other hand, the intravenous injection of TATD to rabbit or man caused the higher lipoic acid level in blood compared with the injection of lipoic acid. This high level of lipoic acid was maintained for 4 hours after injection, while the lipoic acid in blood after injection of lipoic acid reduced to normal value after 1 hour. This lipoic acid level elevated by the intravenous injection was ascribed to prominent distribution in blood plasma in contrast with the small amount in erythrocytes. By separation of plasma protein with perchloric acid treatment it was found that the lipoic acid in blood plasma was combined with the protein precipitate.
